
Brentford went up to seventh in the Premier League table, heaping more pressure on bottom club Southampton with a comfortable win at the Gtech Community Stadium.
Ben Mee put the hosts in front, meeting Bryan Mbuemo's cross with a thumping header in the 41st minute.
And three minutes later Brentford doubled their lead after Mbuemo dispatched Yoane Wissa's cut-back into the bottom corner.
Mathias Jensen added a third nine minutes from time, nodding in a Rico Henry cross from close range.
With relegation rivals Everton edging out Arsenal and Wolves beating Liverpool, defeat left Southampton three points from a position of Premier League safety.
Meanwhile, Brentford extended their unbeaten run to nine matches, their longest in the top flight for 87 years.
Reliver Brentford's win over Southampton and follow Saturday's over actionPride of west London, the Bees know what they are
Brentford's victory moved them above west London rivals Chelsea and Fulham, and they are just six points off a top-four spot.
The Bees, unbeaten in the league since 23 October, always looked the better side against their struggling opponents.
Thomas Frank's team nearly took the lead in the eighth minute when Wissa rounded Southampton keeper Gavin Bazunu only to strike the ball against the crossbar from a tight angle.
And after a flurry of half-chances, the hosts went in front through Mee's header, with the defender rising highest to meet Mbuemo's enticing cross.
Mee was checked for concussion immediately after his opener having clashed heads with a Saints defender, but was able to carry on as the Bees doubled their lead through Mbuemo minutes later.
Brentford's top scorer Ivan Toney had an effort cleared off the line midway through the second half before Jensen rounded off the win with a header into the far corner.
More to follow.
Line-ups
Brentford
Formation 4-3-3
1Raya2HickeySubstituted forRoerslevat 61'minutes5Pinnock16Mee3Henry10DasilvaSubstituted forJaneltat 61'minutes6Nørgaard8JensenSubstituted forDamsgaardat 82'minutes19MbeumoSubstituted forM Jorgensenat 82'minutes17ToneyBooked at 64mins11WissaSubstituted forSchadeat 74'minutesSubstitutes
9Schade13M Jorgensen14Ghoddos20Ajer23Lewis-Potter24Damsgaard27Janelt30Roerslev34CoxSouthampton
Formation 4-2-3-1
31Bazunu14Bree35Bednarek22SalisuBooked at 90mins15Perraud27DialloSubstituted forSulemanaat 45'minutes45LaviaBooked at 59minsSubstituted forAlcarazat 65'minutes23EdozieSubstituted forWalcottat 65'minutes8Ward-Prowse24ElyounoussiSubstituted forOnuachuat 45'minutes10AdamsSubstituted forA Armstrongat 81'minutesSubstitutes
3Maitland-Niles4Lyanco7Aribo9A Armstrong12Onuachu13Caballero20Sulemana26Alcaraz32WalcottReferee:Darren Bond
Attendance:17,051
Live Text
Match ends, Brentford 3, Southampton 0.
Second Half ends, Brentford 3, Southampton 0.
Attempt saved. Adam Armstrong (Southampton) left footed shot from outside the box is saved in the centre of the goal. Assisted by Theo Walcott.
Delay over. They are ready to continue.
Delay in match because of an injury Ethan Pinnock (Brentford).
Attempt missed. Mads Roerslev (Brentford) right footed shot from the right side of the box is high and wide to the right. Assisted by Mikkel Damsgaard.
Mohammed Salisu (Southampton) is shown the yellow card for a bad foul.
Foul by Mohammed Salisu (Southampton).
Ivan Toney (Brentford) wins a free kick in the attacking half.
Attempt saved. Paul Onuachu (Southampton) header from the centre of the box is saved in the top centre of the goal. Assisted by James Bree with a cross.
Attempt blocked. Theo Walcott (Southampton) right footed shot from outside the box is blocked.
Corner, Southampton. Conceded by Christian Nørgaard.
Delay over. They are ready to continue.
Delay in match because of an injury Rico Henry (Brentford).
Substitution, Brentford. Mikkel Damsgaard replaces Mathias Jensen.
Substitution, Brentford. Zanka replaces Bryan Mbeumo.
Substitution, Southampton. Adam Armstrong replaces Che Adams.
Goal! Brentford 3, Southampton 0. Mathias Jensen (Brentford) header from the centre of the box to the bottom right corner. Assisted by Rico Henry with a cross.
Foul by James Ward-Prowse (Southampton).
Rico Henry (Brentford) wins a free kick in the defensive half.