European Challenge Cup
Ospreys (26) 36
Tries: Beard, Morgan, R Davies, Lake, Walsh, Kasende Cons: Edwards 3
Scarlets (7) 14
Tries: Murray, James Cons: Lloyd 2
Ospreys gained revenge over local rivals Scarlets to set up a European Challenge Cup home quarter-final against Lyon next Saturday.
Mark Jones' side lost 38-22 in Llanelli in the United Rugby Championship (URC) last weekend, but avenged that defeat in the last 16 of Europe's second tier tournament with a convincing six-try display in Swansea.
With half-backs Reuben-Morgan Williams and Dan Edwards orchestrating matters, tries from Adam Beard, Jac Morgan, Rhys Davies, Dewi Lake, Jack Walsh and Daniel Kasende overwhelmed Scarlets in this all-Welsh knockout affair.
Scarlets could only respond with tries from Wales duo Blair Murray and Eddie James with Dwayne Peel's side now left to attempt to reach the URC play-offs.
Ospreys will face Lyon on Saturday, 12 April in Swansea in the Challenge Cup final eight for a place in the semi-final against Connacht or Racing 92.
Scarlets' boss Dwayne Peel made two tweaks to his side with hooker Ryan Elias and lock Jac Price coming in for Marnus van der Merwe and Alex Craig.
In contrast, Ospreys head coach Jones, who had rested ersonnel last weekend, rung the changes.
Full-back Walsh, wings Kasende and Keelan Giles, centre Keiran Williams and scrum-half Morgan-Williams came in, while Wales hooker Lake returned to the Ospreys pack for his first start since mid December.
Prop Tom Botha and lock Davies were also promoted from the bench with flanker Justin Tipuric returning after recovering from a back problem.
It appeared to have worked as Ospreys made a storming start with a second-minute try created by Morgan, Walsh and Davies and powerfully finished by Beard.
Edwards converted and made a brilliant break to create the second score for captain Morgan.
Ospreys had led the Welsh derby 17-0 after 15 minutes in Llanelli, but on that occasion the home side stormed back with six tries to record their first win in this derby since January 2022.
This time Scarlets initially responded with captain Josh Macleod gaining a turnover penalty before some fancy footwork from Macs Page created the opportunity for Murray to scamper over for Ioan Lloyd to convert.
Ospreys were not to make the same mistakes on consecutive weekends.
There had been some pre-match needle with Ospreys prop Gareth Thomas admitting his side had been riled by comments made by Scarlets number eight Taine Plumtree who said Scarlets would show their rivals "no respect".
Tipuric and Vaea Fifita exchanged pleasantries before Henry Thomas and Morgan Morris squared up to each other.
The hosts were rampant and during the Ospreys' onslaught, wing Giles was denied on a couple of occasions before prop Thomas was held up by the Scarlets defence over the visitors' line.
The incessant pressure told with lock Davies charging over before Lake was driven over for Ospreys' fourth try as the home side led 26-7 at half-time.
Scarlets were looking for some inspiration and made three forward changes at the interval with van der Merwe, Craig and Sam Wainwright coming on.
Hooker Van der Merwe made an immediate impression with a trademark turnover before he was held up over the Ospreys line.
The home side weathered the storm and a breakaway was finished off by Walsh who slipped through two attempted tackles.
That took the wind out of Scarlets' sails and Kasende crossed for the sixth score. Scarlets gained a late consolation try through Wales centre James.
In an almost perfect Sunday evening in Swansea, Ospreys lost influential Morgan-Williams to a head injury which means he will be a major quarter-final doubt with the six-day turnaround, although Kieran Hardy could return.
Ospreys: Jack Walsh; Dan Kasende, Evardi Boshoff, Keiran Williams, Keelan Giles; Dan Edwards, Reuben Morgan-Williams; Gareth Thomas, Dewi Lake, Tom Botha, Rhys Davies, Adam Beard, Jac Morgan (capt), Justin Tipuric, Morgan Morris.
Replacements: George McGuigan, Garyn Phillips, Ben Warren, James Fender, Morgan Morse, Luke Davies. Owen Williams, Iestyn Hopkins.
Scarlets: Blair Murray; Macs Page, Joe Roberts, Eddie James, Ellis Mee; Ioan Lloyd, Gareth Davies; Alec Hepburn, Ryan Elias, Henry Thomas, Jac Price, Sam Lousi, Vaea Fifita, Josh Macleod (capt), Taine Plumtree.
Replacements: Marnus van der Merwe, Sam O'Connor, Sam Wainwright, Alex Craig, Jarrod Taylor, Efan Jones, Ioan Nicholas, Dan Davis.
Referee: Matthew Carley (RFU)
Assistant referees: Anthony Woodthorpe & Jamie Leahy (RFU)
TMO: David Rose (RFU).