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Tom Curry scored twice as Sale's forwards dominated at The Stoop
Gallagher Premiership
Harlequins: (15) 29
Tries: Kenningham, Murley, Anderson, Jibulu Cons: Smith 3 Pens: Smith
Sale: (26) 43
Tries: Cowan-Dickie, T Curry 2, Opoku-Fordjour, Hill, JL de Preez, Roebuck Cons: R du Preez 4
England's Tom Curry scored two tries as Sale Sharks overpowered Harlequins and strengthened their claims for a Premiership play-off place.
The lead changed hands four times in a pulsating first half, but scores from Luke Cowan-Dickie, Curry, Asher Opoku-Fordjour, Jonny Hill, Jean-Luc du Preez and Tom Roebuck secured a vital win for the visitors.
Quins had taken an early lead through Jack Kenningham and would add three more tries through vice-captain Cadan Murley, Cameron Anderson and Sale-bound Nathan Jibulu as they saw their hopes of a semi-final place take a big hit.
Victory moved Sale up to third in the table with 44 points, with Saracens, Gloucester and Leicester Tigers all yet to play.
Harlequins remain seventh with 38 points and could be as many as eight points off the play-offs by the end of the weekend.
Sale stars impress with Lions announcement on horizon
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George Ford played a key role for Sale at fly-half
With Andy Farrell set to announce his squad next month for the British and Irish Lions' upcoming tour of Australia, many eyes are on who is performing in the final weeks of the domestic season.
And it was Sale's stars who shone in the sunshine at The Stoop, after they recovered from a slow start and the hosts taking a 10-0 lead.
All seven of the Sharks' tries were scored by forwards as they dominated the Harlequins pack.
Cowan-Dickie was tireless in the front row and bulldozed his way through in a quick attack from the maul for his side's first try of the match.
The first half was breathless at times as both teams attacked the spaces, and the Sale prop never stopped running, chasing down a long kick from Ford when players from both sides were tiring.
With competition fierce among the fly-halves for spots on the plane, Ford provided a reminder of his quality with both hands and feet, central to every move forward from the visitors.
Curry's remarkable return from hip surgery continued with two tries, powering over the line for his first before swivelling through two last-gasp challenges for his second.
Another tough day for Quins defence
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Asher Opoku-Fordjour scored Sale's second try at Harlequins
Harlequins conceded more than 40 points for the third game in a row as they were ultimately well beaten at home.
Danny Wilson's team have now shipped 152 points in their last three outings and face an uphill battle to make the top four.
They made a bright start with Kenningham's early try but struggled to deal with the power of the Sharks' front line as the game progressed.
The impressive Opoku-Fordjour made two powerful long runs, ending with Curry's first try before the 20-year-old scored himself.
Hill and Jean-Luc du Preez were both able to dot down over the line from close range.
The hosts did give themselves hope with late tries from Nathan Jibulu, who will move to Sale in the summer, running into the corner, and then from Anderson, who was a late addition to the side with Nick David ruled out with illness, to bring them within seven points with three minutes left.
But as they pushed for the win at the end, Ben Waghorn's loose pass was gifted straight to Roebuck to run in unchallenged and seal the win for Sharks.
Harlequins: Green; Anderson, Beard, Northmore, Murley; Smith, Care; Baxter, Walker, Lamositele, Herbst, Cunningham-South, Kenningham, Evans, Dombrandt.
Replacements: Jibulu, Els, Jones, Launchbury, Lawday, Gjaltema, Benson, Waghorn.
Sale: Carpenter; Roebuck, R du Preez, Ma'asi-White, Reed; Ford, Warr; Rodd, Cowan-Dickie, Opoku-Fordjour, Bamber, Hill, Van Rhyn, T Curry, JL du Preez.
Replacements: McElroy, McIntyre, John, Dugdale, Andrews, Quirke, Bedlow, Wills.
Referee: Matthew Carley.