Wales fly-half Gareth Anscombe suffered a blow after a groin injury ruled him out of the final World Cup pool game against Georgia in Nantes.
Sam Costelow replaced Anscombe in the starting XV, with Dan Biggar coming onto the replacements' bench.
Number eight Taulupe Faletau was also forced off with an arm injury in the second half of the 43-19 win.
Anscombe suffered the injury in the warm-up and left the field in distress.
Biggar himself was not initially selected for the Georgia game after suffering a pectoral injury against Australia.
Anscombe had replaced Biggar in the early stages of the win over the Wallabies 13 days ago and produced a man-of-the-match performance by kicking 23 points.
"He [Anscombe] did some kicking before the game and felt something in his groin before kick-off," Wales head coach Warren Gatland told ITV.
"With Taulupe Faletau, I haven't spoken to the medics but it didn't look great, did it?"